Nature Medicine 2025: global pfhrp2/3 deletion risk

A key recent output is our Nature Medicine (2025) paper on the global risk of selection and spread of Plasmodium falciparum pfhrp2/3 deletions.

• Paper: https://doi.org/10.1038/S41591-025-03974-3
• Related modelling background: eLife 2017 pfhrp2 deletion modelling
• Related software: hrp2malaRia and hrpup

This work builds on several years of modelling, surveillance, and policy-facing analysis around malaria rapid diagnostic test performance. The central question is an operational one: where and when might pfhrp2/3 deletions undermine diagnosis, and how should surveillance adapt?

The paper links directly to my broader Malaria research and WHO-facing policy support activities.